About the Endometrial Receptivity Array (ERA) test

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Recently the Endometrial Receptivity Array [ERA] test has been in the news. Here is a post from one of the Reproductive Endocrinology/Infertility fellows at UConn School of Medicine/Center for Advanced Reproductive Services on the subject. If you are wondering if the ERA test is right for you please check with your Center physician.

Endometrial Receptivity Array [ERA]

Fertility treatment is the exemplary model for personalized medicine, so in many cases evaluating the endometrium is no different. Every couple needs a different dose of stimulation medications, different lengths of treatment, different types of fertilization, all in an effort to maximize that couple’s chance of conceiving. So it makes sense that in some cases the endometrium lining the uterine cavity, where implantation occurs, requires some personalization as well. The Endometrial Receptivity Array, or ERA, is designed to detect the proper “window of implantation” for a woman based on the genes that her endometrium is expressing on various days around the time of typical implantation. The majority of women may not require this extra step in assessment, which can add to the cost and invasiveness of treatments, because most women can expect implantation to occur at a standard window of time after the LH surge. However, for a subset of women, often including those whose embryos have failed to implant after multiple rounds of IVF, this test may be a worthy and rewarding investment.

If your doctor recommends an ERA, you can expect to take up to one month to complete a “mock” embryo transfer cycle which includes one or more endometrial biopsies performed in the Center’s exam room (via speculum exam) at the time when an embryo transfer would be done. The test will determine if the “standard” receptive day is actually too early or too late for you, adjusting your plan for the real cycle. It is not always a magic bullet (or we would use it for EVERYONE), but for many patients we have seen this test make the difference needed to finally get that, “You’re pregnant” call from the team.

To view a video on the test, click here.

For more information on the test, go to http://www.igenomix.com/

Leah Kaye, MD
2nd Year REI Fellow
UConn School of Medicine
Center for Advanced Reproductive Services

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